Regeneration: Organizing the Blastema in Planarians
نویسندگان
چکیده
منابع مشابه
Regeneration: Organizing the Blastema in Planarians
The processes that trigger regeneration after injury and link new and old tissue are not fully understood. New findings indicate that, after decapitation, planarians build an organizing center from stem cells at the old midline that directs head patterning and outgrowth.
متن کاملRegeneration and pattern formation in planarians III. Evidence that neoblasts are totipotent stem cells and the source of blastema cells
In most regenerating systems, blastema cells arise by dedifferentiation of functional tissue cells. In planarians, though, it is still debatable whether dedifferentiated cells or a population of undifferentiated cells, the neoblasts, are the main source of blastema cells. Moreover, it is unclear whether in the intact organisms neoblasts are quiescent cells 'reserved' for regeneration or if they...
متن کاملThe mammalian blastema: regeneration at our fingertips
In the mouse, digit tip regeneration progresses through a series of discrete stages that include inflammation, histolysis, epidermal closure, blastema formation, and redifferentiation. Recent studies reveal how each regenerative stage influences subsequent stages to establish a blastema that directs the successful regeneration of a complex mammalian structure. The focus of this review is on ear...
متن کاملRegeneration and pattern formation in planarians
In planarians, blastema cells do not divide, and growth of blastema is thought to result from the steady accumulation, beneath the wound epithelium, of undifferentiated cells produced by cell division in the stump. However, whether these cells come only from local stump sources or whether cells placed far from the wound can also participate, after long-range migrations, in the growth of blastem...
متن کاملStem cells and regeneration in planarians.
Understanding stem cells is a major goal of current research because of its potential medical applications. Although great advances have been made, such as the culturing and differentiation of embryonic stem cells and reprogramming of cell fates, many basic questions remain unanswered. Describing the mechanisms underlying regeneration will help to understand the biology of stem cells and theref...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2017
ISSN: 0960-9822
DOI: 10.1016/j.cub.2017.01.057